CuI/l-proline-catalyzed coupling of 2-halotrifluoroacetanilides with beta-keto esters in anhydrous DMSO under the action of Cs2CO3 at 40-80 degrees C produces polysubstituted 2-(trifluoromethyl)indoles in good to excellent yields. This reaction is suggested to occur via a novel coupling/condensation/deacylation mechanism, and many functional groups are tolerated under these conditions.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: