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April 1, 2023Journal of Medical CasesOpen Access

Vasopressin administration for refractory septic shock induced a rapid development of purpura fulminans within one day, which improved upon discontinuation of the drug.

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Why the study?

Purpura fulminans is a rarely encountered rapidly evolving ischemic dermatological emergency that has rarely been documented secondary to vasopressin.

Population

One 55-year-old male admitted to the ICU for DKA and septic shock

Design

Case report

Key result

Vasopressin administration for refractory septic shock induced a rapid development of purpura fulminans within one day, which improved upon discontinuation of the drug.

Authors

VAVanessa AwadPNPreeth NairSRSasmit Roy

Discussion

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Member takes

Overview

Vasopressin may trigger purpura fulminans in septic shock; hypothesis-generating case leaves association unconfirmed.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P
Population
A 55-year-old male with diabetes and methamphetamine abuse who developed purpura fulminans after receiving vasopressin for refractory septic shock.
E
Exposure
Vasopressin (added to norepinephrine and phenylephrine for refractory septic shock)
O
Outcome
Development of purpura fulminanssafety

Vasopressin use in septic shock may rarely be associated with the rapid development of purpura fulminans.

Limitations

  • Single case report
  • Pathophysiology of vasopressin-induced purpura fulminans remains poorly understood

Cite This Study

Awad et al. (2023) conducted a case report in Purpura fulminans (n=1). Vasopressin was evaluated on Development and resolution of purpura fulminans. Vasopressin administration for refractory septic shock induced a rapid development of purpura fulminans within one day, which improved upon discontinuation of the drug.

synapsesocial.com/papers/6a93ea476ba650b41c6d1157https://doi.org/10.14740/jmc4062
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