Two hypothetical types of structure, derived by folding from basic patterns containing extended zigzag polypeptide chains, joined together by hydrogen bridges, are described and critically discussed. The (idealized, undistorted) 288-residue open-ended octahedron model has suitable horizontal dimensions but is somewhat too large vertically to fit satisfactorily into the unit cell of air-dried insulin.
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Maurice L. Huggins (1940) studied this question.
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