The immunization Agenda 2030: A vision of global impact, reaching all, grounded in the realities of a changing world

The launch of the Immunization Agenda 2030 (IA2030) came at an extraordinary and turbulent time in our collective experience.The COVID-19 pandemic erupted into all our lives, stopping dead in their tracks economies, education systems, human connections and many lives -lives of persons we loved.It has brought vaccines and immunizations back into the spotlight.In a single year we witnessed the emergence of a novel pathogen, the collective sprint to design, develop, evaluate, and manufacture numerous successful vaccines and deliver hundreds of millions of doses worldwide.This is a testament not only to the power, ingenuity and shared responsibility of collaborative science, but of our shared humanity.The acute phase of the pandemic will be controlled and a return to some sort of new normal will be achieved.COVID-19 vaccines are expected to make a major contribution toward that goal, and this remarkable achievement of vaccine science will need to be accompanied by continued political commitment, global economic partnership, and public engagement.At time of writing, the longerterm trajectory of SARS CoV-2 and the vaccine strategies to constrain its full impact are still unfolding, yet it is clear that the global vaccine ecosystem, which touches every community of every country around the world is being put to the test.Vaccine programs in the late 20th century and early 21st have contributed to the receding of infections previously ravaging human populations.Yet stubborn stagnation of vaccine coverage during the last decade, and severe backsliding during the pandemic years, has meant their full value is yet to be realized.Polio is stubbornly clinging to the last corners of the world, resurgent measles epidemics in countries of all means have taken hundreds of thousands of lives, and life-threatening diseases like diphtheria, meningitis, pneumonia, and diarrhea remain a reality for too many.This is a stark reminder that we cannot be lulled into a false sense of complacency about the need for vaccination and that achieving high coverage, with equity is anything but routine.We have to leverage this momentum to not only use vaccines as a critical tool to address the pandemic but to ensure equitable coverage of all available vaccines to prevent outbreaks and address health threats for individuals, in every community.The impact of vaccines to reduce morbidity and mortality in a highly cost-effective way is well quantified and well known.Their true impact can only be realized if they are accessible to everyone, particularly those who need them most.The IA2030 therefore, is a vision for our present and future world in which vaccines are available and accessible and provide protection from disease, fostering health and making possible life's opportunities to all, no matter the vagaries of birth, geography or economy.It is a vision co-created through iterative input from and representation of wide segments of the global community, stakeholders and end beneficiaries.A world where everyone, everywhere, at every age, fully benefits from vaccines for good health and wellbeing.This vision articulates a goal of reduced mortality and