What question did this study set out to answer?

To identify and isolate an antioxidative peptide from the marine tunicate Styela plicata and evaluate its protective activity against free radical-induced oxidative damage.

January 1, 2016RSC Advances

A hexameric peptide purified from Styela plicata protects against free radical-induced oxidative stress in cells and zebrafish model

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To identify and isolate an antioxidative peptide from the marine tunicate Styela plicata and evaluate its protective activity against free radical-induced oxidative damage.
Hydrolyzed Styela plicata protein using nine commercial proteases to prepare bioactive peptide hydrolysates.
Evaluated free radical-scavenging activity across hydrolysates using an electron spin resonance (ESR) spectrometer.
Purified the active hexameric peptide and tested its protective efficacy in cellular and zebrafish models.
Protease-mediated enzymatic hydrolysis of Styela plicata successfully generated fractions with potent free radical-scavenging activity on ESR spectroscopy.
The purified hexameric peptide provided significant protection against free radical-induced oxidative stress in both in vitro cell cultures and in vivo zebrafish.

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Implication

Preclinical study demonstrates antioxidant protection against free radicals in zebrafish and cell models, suggesting therapeutic potential for marine peptides.

Cite This Study

Ko et al. (2016) studied this question.

synapsesocial.com/papers/6a93eb3817af41b48a872bbf https://doi.org/10.1039/c6ra06308j

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Implication

Preclinical study demonstrates antioxidant protection against free radicals in zebrafish and cell models, suggesting therapeutic potential for marine peptides.

A hexameric peptide purified from Styela plicata protects against free radical-induced oxidative stress in cells and zebrafish model

Key Points

Discussion

Implication

Cite This Study

A hexameric peptide purified from Styela plicata protects against free radical-induced oxidative stress in cells and zebrafish model

Key Points

Discussion

Implication

Cite This Study

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