Gastric Erosions in the Rat: Effects of Immobilization at Different Points in the Activity Cycle

Predictable, cyclic patterns of activity were obtained from 30 male rats. Seventeen of these were subjected to physical immobilization just as they were approaching their period of peak activity and thirteen animals were restrained during the inactive phase of their cycle. Eight animals were found to have gastric erosions following the immobilization. All of these came from the group immobilized during the time they would have been in the active phase of their particular cycle.