Clinical observation demonstrates rapid dissolution of agarose-based dermal fillers using water for injection and saline in five patients, highlighting high safety and reversibility.
Key Points
To evaluate the effect of normal saline and water for injection on the rate of induced degradation of agarose-based dermal filler gel both in vitro and in vivo.
Evaluated the in vitro physicochemical and rheological degradation of 1.5% and 2.5% agarose-based gels exposed to 0.9% sodium chloride and water for injection.
Performed a clinical observation in 5 patients using soft tissue ultrasound imaging to monitor the in vivo dissolution of the agarose gel filler.
In vitro testing showed both solutions degraded the gel, but exposure to water for injection resulted in the lowest gel stability and significantly faster degradation than 0.9% sodium chloride.
In vivo soft-tissue ultrasound revealed that water for injection provided greater dissolution capacity than normal saline, achieving complete degradation of the agarose-based filler bolus after a single application.