Key result
Experimental subarachnoid hemorrhage in rabbits caused severe histopathological lung changes in non-surviving animals compared to minimal changes in survivors (p<0.01).
Why the study?
Does experimental subarachnoid hemorrhage cause histopathological changes in lung tissue in rabbits?
Does experimental subarachnoid hemorrhage cause histopathological changes in lung tissue in rabbits?
Experimental subarachnoid hemorrhage in rabbits leads to significant histopathological lung changes, suggesting a mechanism for neurogenic pulmonary edema and pulmonary hypertension.
Suggests neurogenic pulmonary edema mechanism in experimental subarachnoid hemorrhage; leaves open human translation.
OBJECTIVE: To investigate the effects of subarachnoid hemorrhage (SAH) on lung tissue. METHODS: We conducted this study on 20 rabbits in the Ataturk University Medical Faculty, Erzurum, Turkey in 2005. Experimental SAH was applied to all animals under general anesthesia. After 20 days, all animals were sacrificed. Their lungs were examined histopathologically. RESULTS: Foamy hemorrhagic parenchymal lesions, alveolar rupture, and subintimal fluid collection in the pulmonary vasculature were observed in the lungs of the non-surviving animals. However, minimal changes were found in the lungs of the surviving animals (p<0.01). CONCLUSION: Our results suggest that luminal narrowing of the lung vessels due to subintimal fluid collection plays an important role in the development of pulmonary hypertension and neurogenic pulmonary edema in SAH.
No takes yet. Share an insight, caveat, or question.
Gündoğdu et al. (2006) studied Subarachnoid hemorrhage (n=20). Experimental subarachnoid hemorrhage was evaluated on Histopathological changes in the lungs (p=<0.01). Experimental subarachnoid hemorrhage in rabbits caused severe histopathological lung changes in non-surviving animals compared to minimal changes in survivors (p<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: