What does this research mean for the field?

Host immunogenetic variations, particularly in immunoregulatory cytokines like IL10 and TGFB1, shape the balance between immune activation and tolerance, thereby influencing susceptibility and disease persistence in human echinococcosis. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Synthesize current evidence on host genetic determinants that modulate immune responses, susceptibility, and disease persistence in cystic echinococcosis and alveolar echinococcosis.

August 30, 2026Parasites Hosts and DiseasesOpen Access

Host genetic regulation of immune tolerance and disease persistence in human echinococcosis

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Authors

ESEmad Shamsan CLC. X. Liu FHFan Haining

Discussion

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Overview

Review reveals host immunogenetic polymorphisms regulate immune tolerance and chronic infection in human echinococcosis, indicating potential targets for personalized risk stratification and therapy.

Key Points

Synthesize current evidence on host genetic determinants that modulate immune responses, susceptibility, and disease persistence in cystic echinococcosis and alveolar echinococcosis.
Narrative synthesis of published studies examining host genetic variants, immunoregulatory cytokines, and innate and adaptive immune pathways in human echinococcosis.
Polymorphisms in regulatory cytokine genes, notably IL10 and TGFB1, promote an anti-inflammatory profile that suppresses protective effector responses and facilitates parasite persistence.
Cytokine gene variants in IL4, IL13, and IFNG modulate the Th1/Th2 response balance, while human leukocyte antigen class II alleles demonstrate population-specific associations with infection susceptibility.

Cite This Study

Shamsan et al. (2026) studied this question.

synapsesocial.com/papers/6a93f0c06c1a8fb52e79d2ab https://doi.org/10.3347/phd.26012

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August 30, 2026Parasites Hosts and DiseasesOpen Access

Host genetic regulation of immune tolerance and disease persistence in human echinococcosis

View Full Paper

Ask AI

Bookmark

Authors

ESEmad Shamsan CLC. X. Liu FHFan Haining

Discussion

Member takes

Overview

Review reveals host immunogenetic polymorphisms regulate immune tolerance and chronic infection in human echinococcosis, indicating potential targets for personalized risk stratification and therapy.

Key Points

Synthesize current evidence on host genetic determinants that modulate immune responses, susceptibility, and disease persistence in cystic echinococcosis and alveolar echinococcosis.
Narrative synthesis of published studies examining host genetic variants, immunoregulatory cytokines, and innate and adaptive immune pathways in human echinococcosis.
Polymorphisms in regulatory cytokine genes, notably IL10 and TGFB1, promote an anti-inflammatory profile that suppresses protective effector responses and facilitates parasite persistence.
Cytokine gene variants in IL4, IL13, and IFNG modulate the Th1/Th2 response balance, while human leukocyte antigen class II alleles demonstrate population-specific associations with infection susceptibility.

Cite This Study

Shamsan et al. (2026) studied this question.

synapsesocial.com/papers/6a93f0c06c1a8fb52e79d2ab https://doi.org/10.3347/phd.26012

View Full Paper

Ask AI

Bookmark