Key result
At four months post-STEMI, NT-proBNP was independently associated with increased aortic stiffness and was the strongest predictor for high aortic stiffness (AUC 0.82).
Why the study?
Are biomarkers of hemodynamic stress associated with aortic stiffness at a chronic stage post-STEMI?
Cross-Sectional (n=54)
No
Are biomarkers of hemodynamic stress associated with aortic stiffness at a chronic stage post-STEMI?
NT-proBNP and MR-proADM are independently associated with increased aortic stiffness four months post-STEMI, suggesting their potential utility as predictors of vascular stiffness.
NT-proBNP may aid post-STEMI stiffness risk stratification; hypothesis-generating and requires prospective validation before clinical use.
We aimed to evaluate the association between biomarkers of hemodynamic stress and aortic stiffness assessed at a chronic stage after ST-segment elevation myocardial infarction (STEMI). Fifty-four patients four months after acute STEMI were enrolled in this cross-sectional, single-center study. N-terminal pro B-type natriuretic peptide (NT-proBNP), mid-regional pro-A-type natriuretic peptide (MR-proANP) and mid-regional pro-adrenomedullin (MR-proADM) levels were measured by established assays. Aortic stiffness was assessed by the measurement of pulse wave velocity using velocity-encoding, phase-contrast cardiovascular magnetic resonance imaging. NT-proBNP, MR-proANP and MR-proADM concentrations were all correlated with aortic stiffness in univariate analysis (r = 0.378, r = 0.425, r = 0.532, all p < 0.005, respectively). In multiple linear regression analysis, NT-proBNP (ß = 0.316, p = 0.005) and MR-proADM (ß = 0.284, p < 0.020) levels were associated with increased aortic stiffness independently of age, blood pressure and renal function. In receiver operating characteristic analysis, NT-proBNP was the strongest predictor for high aortic stiffness (area under the curve: 0.82, 95% CI 0.67 - 0.96). At a chronic stage after STEMI, concentrations of biomarkers for hemodynamic stress, especially NT-proBNP, are positively correlated with aortic stiffness. These biomarkers might also be useful as predictors of high aortic stiffness post-STEMI.
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Reinstadler et al. (2015) conducted a cross-sectional in ST-segment elevation myocardial infarction (STEMI) (n=54). Biomarkers of hemodynamic stress (NT-proBNP, MR-proANP, MR-proADM) was evaluated on Prediction of high aortic stiffness (AUC 0.82, 95% CI 0.67 - 0.96, p=0.005). At four months post-STEMI, NT-proBNP was independently associated with increased aortic stiffness and was the strongest predictor for high aortic stiffness (AUC 0.82).
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