Cecal contents 16S rRNA sequencing for CUMS-exposed mice

Q: What does this research mean for the field?

Chronic unpredictable mild stress (CUMS) exposure in mice is associated with specific alterations in the cecal microbiota that are linked to depression. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

李思颖(Siying Li)

doi:10.26036/cnp0010049

August 29, 2026Open Access

Cecal contents 16S rRNA sequencing for CUMS-exposed mice

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Key Points

Characterize cecal microbial community alterations in mice exposed to chronic unpredictable mild stress (CUMS) using high-throughput sequencing.
Extracted and sequenced cecal microbial 16S rRNA genes from mice subjected to chronic unpredictable mild stress (CUMS).
Processed amplicon sequence data using DADA2 for denoising and SILVA v138 for taxonomic annotation.
Archived and made datasets publicly accessible via China National GeneBank DataBase (CNGBdb: CNP0010049).
Identified distinct gut microbial community shifts and specific bacterial taxa associated with stress-induced depressive behavior.
Generated an annotated, repository-deposited 16S rRNA profiling dataset detailing cecal microbiome composition under chronic stress conditions.

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Implication

Animal study reveals depression-linked alterations in cecal microbiota in chronic unpredictable mild stress-exposed mice, highlighting gut microbiome dynamics in depressive phenotypes.

Abstract

Cecal 16S rRNA sequencing of CUMS mice: DADA2 denoising, SILVA v138 annotation, deposited at CNGBdb (CNP0010049), revealing depression-linked microbiota.

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Cite This Study

李思颖(Siying Li) (2026) studied this question.

synapsesocial.com/papers/6a93f1396c1a8fb52e79e028 https://doi.org/10.26036/cnp0010049

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Cecal contents 16S rRNA sequencing for CUMS-exposed mice

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Implication

Abstract

Discussion

Cite This Study

Cecal contents 16S rRNA sequencing for CUMS-exposed mice

Key Points

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Implication

Abstract

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