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Exploratory study reveals high negative predictive value of serum beta-D-glucan for Pneumocystis pneumonia in immunocompromised children, suggesting its utility in ruling out infection.
Serum 1,3-β-D-glucan (BDG) showed high negative predictive value (~99%) for Pneumocystis jirovecii pneumonia (PJP) in 106 non-HIV immunocompromised children, but modest positive predictive value at low prevalence. These exploratory findings suggest BDG may help exclude PJP, pending prospective validation.
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Keldorfer et al. (2026) studied this question.
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