The Anterior Pituitary-Like Hormone

In a previous paper1a preliminary report concerning the effect of pregnancy urine extract2on acne vulgaris was made. This paper comprises a further study of that problem. A review of the literature brings to light several theories regarding the cause of acne but little clinical or experimental evidence in support of them. Constipation, improper diet, lack of exercise and the normal aversion of youth to soap and water are all mentioned in the older textbooks3as probable causes of the condition, but no convincing evidence of their responsibility for it is to be found. Later the microbacillus of Sabouraud was regarded as the specific etiologic factor in the disease until evidence accumulated that "it may be found in myriads in the sebaceous material expressed from the follicles of the nose of practically all adolescents and adults."4Schamberg4suggests that it may be "merely a