The histamine H2‐receptor antagonists burimamide and cimetidine cause inhibition of human skin histamine‐N‐methyl transferase (HMT) in the dose range 10‐3–10‐4 M. Amodiaquin, a recognized inhibitor of animal HMT, also produced dose‐related inhibition of human HMT. These findings may explain the observation that H2‐receptor antagonists enhance certain types of inflammatory response in skin.
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Corbett et al. (1979) studied this question.
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