Abstract.The effect of bendroflumethiazide (Centyl®) on the renal excretion of calcium, magnesium and phosphate has been investigated in 10 normocalcaemic renal stone formers and 10 hyperparathyroid patients to evaluate the effect of diuretic thiazides on calcium metabolism. A significant increase in the tubular reabsorption of calcium and a significant decrease in the tubular reabsorption of magnesium were observed in both groups. A reduction of 52% in renal calcium excretion was found in both groups, being independent of supposed differences in parathyroid hormone secretion but significantly related to the pretreatment urinary calcium excretion. The renal excretion of magnesium and phosphate increased during thiazide administration. Different theories concerning the mechanisms through which diuretic thiazides act on calcium metabolism are discussed. Based on the present results combined with previous investigations, both a direct effect on tubular calcium reabsorption and an effect on bone metabolism are postulated.
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Jørgensen et al. (1973) studied this question.
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