Since the discovery by Lohmann (1932) that reduced glutathione (GSH) is the coenzyme of glyoxalase, several workers have reported that methylglyoxal and GSH form a compound and have suggested that this might be the true substrate for the enzyme or an intermediate in the reaction. Thus Jowett & Quastel (1932) observed that SH groups titratable by iodine decreased when methylglyoxal was added to GSH solution and suggested a reaction sequence: CH3 CH3 CH3 II CO + (GSH) CO + H20 -+ CHOR + (GSH) II CHO HC-OH COGH (GS)
No takes yet. Share an insight, caveat, or question.
Crook et al. (1952) studied this question.