Key result
Postoperative serum and urinary beta-2 microglobulin concentrations were significantly correlated with peritoneal interleukin-6 after elective abdominal surgery.
Why the study?
Are postoperative serum and urinary beta-2 microglobulin concentrations correlated with peritoneal interleukin-6 after elective abdominal surgery?
Observational (n=38)
Are postoperative serum and urinary beta-2 microglobulin concentrations correlated with peritoneal interleukin-6 after elective abdominal surgery?
Serum and urinary beta-2 microglobulin concentrations are closely correlated with peritoneal interleukin-6 following elective abdominal surgery.
May indicate peritoneal inflammation noninvasively; leaves open validation as IL-6 surrogate before any clinical use.
Postoperative peritoneal interleukin-6 (P-IL-6), serum beta-2 microglobulin (SBMG) and urinary beta-2 microglobulin (UBMG) concentrations were examined in 33 patients who underwent various types of abdominal surgery. Similar time-dependent changes in SBMG and UBMG were observed in five other patients who underwent abdominal surgery. SBMG decreased the first day after the operation (1POD), then increased and reached the preoperative level by the third day after the operation (3POD). UBMG started to increase 1POD, reached the maximum 3POD, then decreased. The 1POD SBMG concentration was significantly correlated with P-IL-6, and 3POD UBMG was also significantly correlated with P-IL-6. These findings indicate that serum and urinary beta-2 microglobulin concentrations are closely correlated with P-IL-6.
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Tsukada et al. (1993) conducted an observational in Elective abdominal surgery (n=38). Elective abdominal surgery was evaluated on Correlations of peritoneal interleukin-6 with serum and urinary beta-2 microglobulin. Postoperative serum and urinary beta-2 microglobulin concentrations were significantly correlated with peritoneal interleukin-6 after elective abdominal surgery.
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