Synthesis and in vitro antitumor activity of some tetraphenylantimony derivatives of exo ‐7‐oxa‐bicyclo[2,2,1] heptane (ene)‐3‐arylamide‐2‐acid

A series of novel tetraphenylantimony derivatives of exo ‐7‐oxa‐bicyclo[2,2,1] heptane (ene)‐3‐arylamide‐2‐acid of the general formula Ph 4 SbO 2 CCHCHCH 2 CH 2 CH(O)HCONHAr (Ar = Ph,4‐ClC 6 H 4 , 4‐BrC 6 H 4 , 3‐BrC 6 H 4 , 4‐F‐3‐ClC 6 H 3 and 4‐ MeC 6 H 4 ) have been synthesized and characterized by elemental analysis, IR, 1 H NMR and mass spectra. The crystal structure of Ph 4 SbO 2 CCHCHCH 2 CH 2 CH(O)HCONHC 6 ­H 4 CH 3 ·CHCl 3 was determined by X‐ray diffraction. Five human neoplastic cell lines (HL‐60, KB, Bel‐7402, BGC‐823 and HCT‐8) were used to screen these compounds. The results indicate that these compounds at 10 µ M show certain in vitro antitumor activities.