Ultra Sensitive Biosensor Based on Impedance Spectroscopy at Microwave Frequencies for Cell Scale Analysis

This paper presents an original approach for biological cell discrimination using impedance spectroscopy analysis at microwave frequency. This method allows a label free analysis really done at the cell scale using high frequency electromagnetic waves as a non-invasive tool to probe the intracellular medium. In this work, the biosensor sensitivity has been especially enhanced thanks to an appropriated design based on resonant microwave sensor. In this way, small electromagnetic wave interaction with micrometric objects can be accurately detected. This concept has been experimentally validated and is illustrated in this paper with measurements achieved on biological neuronal stem type cells.