Key result
A 1-SD increment in log-transformed BNP was associated with a 34% increased risk of cardiovascular events overall, with both BNP and NT-proBNP serving as significantly stronger predictors in women than in men.
Why the study?
Does elevated BNP and NT-proBNP predict cardiovascular events differently in men and women with cardiovascular risk factors?
Observational (n=3,619)
Yes
Does elevated BNP and NT-proBNP predict cardiovascular events differently in men and women with cardiovascular risk factors?
Both BNP and NT-proBNP are significantly stronger predictors of cardiovascular events in women than in men among outpatients with cardiovascular risk factors.
BACKGROUND: Brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are prognostic biomarkers. Although these 2 peptides differ with regard to biological characteristics, there are few reports on the differences between BNP and NT-proBNP with regard to cardiovascular events or according to sex. METHODS AND RESULTS: Between 2005 and 2012, this study analyzed 3,610 of 4,310 Japanese outpatients (mean age, 65 years; men, n=1,664; women, n=1,947) with a history of at least one cardiovascular event who were recruited to the Japan Morning Surge-Home Blood Pressure Study. During an average 4-year follow-up, there were 129 cardiovascular events. Both median BNP (21.1 pg/mL; IQR, 10.9-40.6 pg/mL vs. 16.2 pg/mL, IQR, 7.2-36.2 pg/mL, P<0.001) and median NT-proBNP (54.7 pg/mL; IQR, 30.2-102.6 pg/mL vs. 44.9 pg/mL, IQR, 20.7-92.6 pg/mL, P<0.001) were significantly higher in women than in men. A 1-SD increment in log-transformed BNP (hazard ratio [HR], 2.18; 95% CI: 1.53-3.10) and NT-proBNP (HR, 2.39; 95% CI: 1.73-3.31) was associated with a significant increase in cardiovascular events in women; in men, only NT-proBNP showed this association. There was an interaction between log-transformed BNP (P=0.007) or NT-proBNP (P=0.001) and cardiovascular events according to sex. CONCLUSIONS: Both BNP and NT-proBNP predicted cardiovascular outcomes in a large Japanese clinical population. BNP and NT-proBNP were significantly stronger predictors in women than in men.
No takes yet. Share an insight, caveat, or question.
Taki et al. (2018) conducted an observational in Cardiovascular risk factors or history of cardiovascular disease (n=3,619). 1-SD increment in log-transformed BNP vs. Lower levels was evaluated on First occurrence of a cardiovascular event (fatal and non-fatal stroke, fatal and non-fatal coronary artery disease, sudden death) (HR 1.34, 95% CI 1.10-1.63, p=0.004). A 1-SD increment in log-transformed BNP was associated with a 34% increased risk of cardiovascular events overall, with both BNP and NT-proBNP serving as significantly stronger predictors in women than in men.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: