Key result
In vitro transcribed mRNA (IVT mRNA) technology has advanced significantly, with optimizations in structural components and synthesis enabling its clinical adoption for vaccines and therapeutics.
Why the study?
Following the unprecedented progress of mRNA-based SARS-CoV-2 vaccines, understanding the foundational advances in in vitro transcribed mRNA is key to driving its clinical translation across diverse therapeutic applications.
This review highlights the technological advancements in IVT mRNA that have enabled its rapid clinical translation for vaccines and therapeutics.
mRNA advantages for rapid infectious disease applications remain hypothesis-generating; in vitro data leaves open clinical translation.
The accelerated progress and approval of two mRNA-based vaccines to address the SARS-CoV-2 virus were unprecedented. This record-setting feat was made possible through the solid foundation of research on in vitro transcribed mRNA (IVT mRNA) which could be utilized as a therapeutic modality. Through decades of thorough research to overcome barriers to implementation, mRNA-based vaccines or therapeutics offer many advantages to rapidly address a broad range of applications including infectious diseases, cancers, and gene editing. Here, we describe the advances that have supported the adoption of IVT mRNA in the clinics, including optimization of the IVT mRNA structural components, synthesis, and lastly concluding with different classes of IVT RNA. Continuing interest in driving IVT mRNA technology will enable a safer and more efficacious therapeutic modality to address emerging and existing diseases.
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Kang et al. (2023) reported a review. in vitro transcribed mRNA (IVT mRNA) was evaluated. In vitro transcribed mRNA (IVT mRNA) technology has advanced significantly, with optimizations in structural components and synthesis enabling its clinical adoption for vaccines and therapeutics.
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