Podophyllin Toxicity

Letters and Corrections1 April 1979Podophyllin ToxicityROBERT G. RATE, M.D., JACQUES LECHE, R.PH., CAROL CHERVENAK, R.PH.ROBERT G. RATE, M.D.Search for more papers by this author, JACQUES LECHE, R.PH.Search for more papers by this author, CAROL CHERVENAK, R.PH.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-4-723_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Drs. Stoehr, Peterson, and Taylor in their paper in the September issue (1) warn of the potentially toxic and even fatal complications of local podophyllin therapy. We wish to reinforce their warning and add another case of bone marrow suppression and severe motor/sensory peripheral neuropathy resulting from the aggressive treatment of condyloma acuminata with local podophyllin application.A 20-year-old Navajo woman (157 cm, 55 kg) received local podophyllin treatment for large perineal condyloma acuminata on 22 May 1975. Due to a lack of water at her hogan, she could not wash off the resin, and she returned...References1. STOEHRPETERSONTAYLOR GAW: Systemic complications of local podophyllin therapy. Ann Intern Med 89:362-363, 1978 LinkGoogle Scholar2. DAWSONDUCKWORTHBERNHARDTYOUNG DJHJ: Giant condyloma and verrucous carcinoma of the genital area. Arch Pathol 79:225-231, 1965 MedlineGoogle Scholar3. ROWE R: How I treat condyloma acuminatum. Postgrad Med 47:229-230, 1970 CrossrefMedlineGoogle Scholar4. SWERDLOWSALVATI DE: Condyloma acuminatum. Dis Colon Rectum 14:226-231, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: U.S. Public Health Service Keams Canyon, AZ 86034 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAntitubulin Agents: Colchicine, Vinca Alkaloids, and PodophyllinAntitubulin Agents: Colchicine, Vinca Alkaloids, and PodophyllinBerberidaceae Juss.Role of the Clinical Laboratory in Detecting Plant PoisoningAcute necrotizing myopathy and podophyllin toxicity: report of a fatal caseToxicité systémique de la podophylline : a propos d'une ingestion accidentelle mortelle. Revue de la littératureEncephalopathy and neuropathy following ingestion of a Chinese herbal broth containing podophyllinHealth Hazards Associated with ExtractivesToxische OsteopathienToxische OsteopathienPodophyllum Toxicity: A Report of a Fatal Case and a Review of the Literature 1 April 1979Volume 90, Issue 4Page: 723-723KeywordsBone marrowPeripheral neuropathyToxicity Issue Published: 1 April 1979 PDF DownloadLoading ...