Nebulised drug therapy may be less effective dose inhalers, rather than nebulisers. 14 These are attached to an adapter in the ventilator in patients undergoing mechanical ventilation than in those spontaneously breathing for two circuit and actuated during lung inflation. The method is simple and treatments can be ad-main reasons -firstly, ventilated patients often have severe lung disease associated with airway ministered rapidly. The amount of drug reaching the lungs has been estimated as 1.5-2% in plugging and collapsed segments which limit the spread of aerosols to affected areas, and infants 12 15 and 3.9-5.6% in adults. 16 17 Administration using a metered dose inhaler is secondly, aerosol deposition from nebulisers and metered dose inhalers is reduced during increased by using an aerosol holding chamber 17 and this method may be more efficient mechanical ventilation compared with spontaneous breathing. 1 This is due to a number of than using an inspiratory phase activated jet nebuliser. 16 Arnon et al 18 found that the use of factors including the site of the nebuliser in the ventilator circuit, the ventilator settings, the a metered dose inhaler and an Aerochamber (MV15, Trudell Medical, Canada), attached method of triggering of the nebuliser, and the size of the endotracheal tube. The indications between the Y piece and the endotracheal tube, delivered larger amounts of budesonide to a for nebuliser therapy in mechanically ventilated patients are given in table
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O’Doherty et al. (1997) studied this question.
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