Key result
The Pre-DICTED cohort of 751 adults with pre-diabetes represents a high-risk population with a mean age of 52.5 years and mean BMI of 29.0 kg/m2 that will be used to evaluate an incentivized lifestyle intervention.
Why the study?
The study was designed to describe baseline characteristics of the Pre-DICTED cohort and compare them with other diabetes prevention trial cohorts.
Does an incentivized lifestyle intervention program with stepwise addition of metformin reduce the diabetes conversion rate at 3 years in patients with pre-diabetes compared to standard of care?
RCT (n=751)
Open-label
permuted block randomization
Yes
Does an incentivized lifestyle intervention program with stepwise addition of metformin reduce the diabetes conversion rate at 3 years in patients with pre-diabetes compared to standard of care?
The Pre-DICTED cohort represents an older, higher BMI urban Asian population at high risk of diabetes conversion, with significant ethnic and sex differences in baseline risk factors.
Baseline Pre-DICTED cohort confirms high-risk Asian prediabetes profile; leaves open effectiveness of incentivized program until primary results.
OBJECTIVE: The Pre-Diabetes Interventions and Continued Tracking to Ease-out Diabetes (Pre-DICTED) Program is a diabetes prevention trial comparing the diabetes conversion rate at 3 years between the intervention group, which receives the incentivized lifestyle intervention program with stepwise addition of metformin, and the control group, which receives the standard of care. We describe the baseline characteristics and compare Pre-DICTED participants with other diabetes prevention trials cohort. RESEARCH DESIGN AND METHODS: ), and had pre-diabetes (impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT)). RESULTS: . Twenty-three per cent had both IFG and IGT, 63.9% had isolated IGT, and 13.3% had isolated IFG. Ethnic Asian Indian participants were more likely to report a family history of diabetes and had a higher waist circumference, compared with Chinese and Malay participants. Women were less likely than men to meet the physical activity recommendations (≥150 min of moderate-intensity physical activity per week), and dietary intake varied with both sex and ethnicity. Compared with other Asian diabetes prevention studies, the Pre-DICTED cohort had a higher mean age and BMI. CONCLUSION: The Pre-DICTED cohort represents subjects at high risk of diabetes conversion. The study will evaluate the effectiveness of a community-based incentivized lifestyle intervention program in an urban Asian context.
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Yeung et al. (2022) conducted an RCT in Pre-diabetes (impaired fasting glucose and/or impaired glucose tolerance) (n=751). Incentivized lifestyle intervention program with stepwise addition of metformin vs. Standard of care was evaluated on Development of diabetes at 3 years. The Pre-DICTED cohort of 751 adults with pre-diabetes represents a high-risk population with a mean age of 52.5 years and mean BMI of 29.0 kg/m2 that will be used to evaluate an incentivized lifestyle intervention.
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