Why the study?
Does levofloxacin affect the international normalized ratio (INR) in outpatients receiving long-term warfarin therapy?
Cohort (n=43)
Does levofloxacin affect the international normalized ratio (INR) in outpatients receiving long-term warfarin therapy?
In a small retrospective cohort, the addition of levofloxacin to long-term warfarin therapy did not significantly alter INR values compared to felodipine, though close monitoring remains advisable.
No INR interaction observed in this cohort; leaves open confirmation in larger prospective trials.
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McCall et al. (2004) conducted a cohort in Long-term warfarin therapy (n=43). Levofloxacin vs. Felodipine was evaluated on Mean change between the pre- and post-INR (p=0.65).
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