Key result
The PlA(2) allele of the glycoprotein IIIa receptor was not associated with the prevalence of coronary artery disease (72.6% vs 70.1%; adjusted OR 0.85, 95% CI 0.67-1.08, P=0.19).
Why the study?
Does the Glycoprotein IIIa platelet receptor gene polymorphism (Leu33Pro-PlA(1)/PlA(2) allele) associate with the extent of coronary artery disease in patients undergoing coronary angiography?
Cohort (n=1,518)
Does the Glycoprotein IIIa platelet receptor gene polymorphism (Leu33Pro-PlA(1)/PlA(2) allele) associate with the extent of coronary artery disease in patients undergoing coronary angiography?
Odds Ratio: 0.85 (95% CI 0.67–1.08)
Absolute Event Rate: 72.6% vs 70.1%
p-value: p=.19
The Leu33Pro polymorphism of the GP IIIa subunit is not associated with the extent of coronary or carotid atherosclerosis and should not be regarded as a risk factor.
Does not support PlA(2) testing for CAD risk stratification; leaves open its role in other populations or incident events.
Glycoprotein IIb/IIIa (GP IIb/IIIa) is a key receptor for platelet aggregation and adhesion. We investigated whether a single-nucleotide polymorphism of GP IIIa subunit (Leu33Pro-PlA(1)/PlA(2) allele) is associated with the extent of coronary artery disease (CAD) in a consecutive cohort of 1518 patients undergoing coronary angiography. Significant CAD was defined as at least a stenosis >50% and severe CAD as left main disease and/or trivessel disease. Additionally, carotid intima-media thickness (cIMT) was evaluated in 339 patients. The PlA(2) allele was observed in 458 (30.2%) patients and associated with hypercholesterolemia (P = .03). No difference was observed in the prevalence of CAD (72.6% vs 70.1%, P = .29; adjusted odds ratio, OR [95% confidence interval, CI] = 0.85 [0.67-1.08], P = .19) and severe CAD (27.5% vs 26.5%, adjusted OR [95% CI] = 0.93 [0.72-1.19], P = .55). Furthermore, Leu33Pro polymorphism did not affect cIMT and the prevalence of carotid plaques. Therefore, this polymorphism cannot be regarded as a risk factor for coronary or carotid atherosclerosis.
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Verdoia et al. (2014) conducted a cohort in Coronary artery disease (n=1,518). Glycoprotein IIIa subunit (Leu33Pro-PlA(1)/PlA(2) allele) polymorphism vs. Absence of PlA(2) allele was evaluated on Prevalence of coronary artery disease (stenosis >50%) (adjusted OR 0.85, 95% CI 0.67-1.08, p=.19). The PlA(2) allele of the glycoprotein IIIa receptor was not associated with the prevalence of coronary artery disease (72.6% vs 70.1%; adjusted OR 0.85, 95% CI 0.67-1.08, P=0.19).
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