One hundred seventy-seven basal-cell carcinomas treated by cryotherapy with liquid nitrogen according to a standard protocol had a recurrence rate of 2.3% in a mean of 4.8 years of follow-up. The cryotherapeutic method used freeze-thaw times rather than temperatures measured by thermocouples as indices of adequacy of freeze.
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McLean et al. (1978) studied this question.
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