Некоторые Аспекты Вовлеченности Кишечной Микрофлоры В Патогенезе Развития Расстройств Аутистического Спектра

Autism spectrum disorder (ASD) is a developmental disorder characterized by deficits in social interaction and communication, as well as restricted interests and repetitive behaviors. Research suggests that the gut-brain axis plays an important role in the pathogenesis of autism, as the gut microbiota produces short-chain fatty acids that affect microglia in the central nervous system. Increased intestinal permeability can lead to the production of pro-inflammatory endotoxins and activation of the immune system. Problems with the innate immune response, including impaired cytokine production and monocyte function, are common in ASD. Pro-inflammatory cytokines such as IL-1β, IL-6, and TNFα influence neuroinflammation and behavior. Further research is needed to develop effective therapeutic interventions.