TGF-β and IL-12 conversely orchestrate the formation of CD103+ CD8 tumor-resident memory T cells to regulate response to therapeutic cancer vaccine

This is the authors' abstract. We don't add key points for this paper.

The accumulation of CD103 + CD8 tumor-resident memory T (T RM ) cells is predictive of response to cancer immunotherapy. Here, we show that a therapeutic peptide vaccine controls tumor growth in wild-type mice, but not in CD103-knockout mice. CD8 tumor-infiltrating T lymphocytes include two major T RM subpopulations expressing either CD49a or CD103 integrin, with a subset co-expressing CD103 and Tcf-1. Vaccination induces a decrease in the percentage of Tcf-1 + CD103 + T RM -like cells and expansion of CD49a + T RM displaying an effector/exhausted profile. Tcf-1 + CD103 + T RM -cell density increases in tumors from transgenic mice constitutively expressing active TGF-β-type-2-receptor and wild-type mice challenged with neutralizing anti-IL-12 antibodies. The stimulation of CD8 T cells with recombinant (r)TGF-β combined with anti-CD3 antibodies results in an increase in the proportion of Tcf-1 + CD103 + cells, whereas rIL-12 decreases CD103 expression. These results highlight the opposite effects of TGF-β and IL-12 in the regulation of T RM -cell development and suggest that targeting Tcf-1 + CD103 + CD8 T RM may improve immunotherapy efficacy.