Key result
A lower carotid flow pulsatility index was negatively and independently correlated with the presence of unruptured intracranial aneurysms in healthy older volunteers.
Why the study?
Cases of incidental unruptured intracranial aneurysms discovered on screening magnetic resonance angiography were assessed to identify hemodynamic and atherosclerotic risk factors.
Observational (n=1,376)
No
Lower carotid flow pulsatility index and elevated LDL cholesterol correlate with the presence of unruptured intracranial aneurysms, potentially serving as risk markers to guide screening.
Hypothesis-generating for carotid pulsatility as an aneurysm risk marker; prospective validation needed before screening implications.
Background We assessed cases of incidental unruptured intracranial aneurysm (UIA) discovered on screening magnetic resonance angiography to identify hemodynamic and atherosclerotic risk factors. Methods and Results The data of 1376 healthy older subjects (age range, 31-91 years) without cerebro- or cardiovascular diseases who underwent brain magnetic resonance angiography as part of a medical checkup program at a health screening center were examined retrospectively. We looked for an increase in classical risk factors for UIAs (age, sex, hypertension, and smoking) and laboratory data related to lifestyle diseases among subjects with UIAs. Brachial-ankle pulse wave velocity, central systolic blood pressure, radial augmentation index, and carotid flow pulsatility index were also compared between those with and without UIAs. We found UIAs in 79 (5.7%) of the subjects. Mean age was 67.1±9.0 years, and 55 (70%) were women. Of the 79 aneurysms, 75 (95%) were in the anterior circulation, with a mean diameter of 3.1 mm (range, 2.0-8.0 mm). Subjects with UIAs were significantly older and had more severe hypertension. The carotid flow pulsatility index was significantly lower in subjects with UIAs and negatively and independently correlated with UIAs. Tertile analysis stratified by carotid flow pulsatility index revealed that subjects with lower indices had higher levels of low-density lipoprotein cholesterol. Conclusions The presence of UIAs correlated with lower carotid flow pulsatility index and elevated low-density lipoprotein cholesterol in the data from a population of healthy older volunteers. A reduced carotid flow pulsatility index may affect low-density lipoprotein cholesterol elevation by some molecular pathways and influence the development of cerebral aneurysms. This may guide aneurysm screening indications for institutions where magnetic resonance angiography is not routine.
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Igase et al. (2021) conducted an observational in Unruptured intracranial aneurysms (n=1,376). Carotid flow pulsatility index vs. Subjects without unruptured intracranial aneurysms was evaluated on Presence of unruptured intracranial aneurysms (UIAs). A lower carotid flow pulsatility index was negatively and independently correlated with the presence of unruptured intracranial aneurysms in healthy older volunteers.
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