The catalytic properties of chitosan aerogel for the direct asymmetric aldol reaction in water assisted by various surfactants and acid co‐catalysts have been evaluated by employing a range of donor and acceptor systems. A beneficial effect on both the yields and enantioselectivities was observed, and the combination of surfactants and acid co‐catalysts has proven particularly useful in the case of heterocyclic ketone donors.
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Gioia et al. (2012) studied this question.
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