Metabolism of Fluoroacetate in the Skink (Tiliqua rugosa) and the Rat (Rattus norvegicus)

Administration of 100 mg sodium fiuoroacetate (compound 1080) per kilogram body weight to T. rugosa resulted in a 3 ·4-fold increase in plasma citrate levels 48 h after dosing while administration of 3 mg sodium fiuoroacetate per kilogram body weight to R. norvegicus produced a fivefold increase in plasma citrate levels within 4 h. Administration of 300 mg sodium fiuoroacetate per kilogram body weight reduced the oxygen consumption of the skink by between 2·5 and 11 % while in the rat, 2 mg sodium fiuoroacetate per kilogram body weight reduced oxygen consumption by between 28 and 57%.