Key result
Intramuscular testosterone treatment in hypogonadal men significantly reduced mean serum GHBP levels from 0.98 to 0.60 nmol/L (P=0.0003), independent of GH mediation.
Why the study?
Does testosterone treatment reduce serum GHBP concentrations in hypogonadal men?
Population
38 adult men, comprising 20 normal men and 18 hypogonadal men, matched for age and body mass index.
Comparison
Intramuscular testosterone treatment. vs Pre-treatment baseline and untreated normal men.
Design
Cohort
Authors
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Testosterone was associated with reduced GHBP in hypogonadism; leaves open effects on GH signaling and clinical outcomes.
Does testosterone treatment reduce serum GHBP concentrations in hypogonadal men?
Absolute Event Rate: 0.6% vs 0.98%
p-value: p=0.0003
Testosterone treatment pharmacologically reduces serum GHBP levels in hypogonadal men independent of endogenous GH-secretory status.
Ip et al. (1995) studied Hypogonadism (n=38). Testosterone enanthate vs. Baseline (untreated hypogonadal state) was evaluated on Serum GHBP concentration (p=0.0003). Intramuscular testosterone treatment in hypogonadal men significantly reduced mean serum GHBP levels from 0.98 to 0.60 nmol/L (P=0.0003), independent of GH mediation.
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