The ABC-Death Score for Mortality Prediction in Patients With Atrial Fibrillation Undergoing Catheter Ablation

Figures

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  Figure 1. Cumulative Event Rate of Mortality Risk by ABC-Death Score Categories Cumulative event rate curves for all-cause mortality (A) and cardiac mortality (B) using Kaplan-Meier method in low-risk (0%-2%, red line), intermediate-risk (2%-5%, green line), and high-risk (>5%, blue line) stratified by ABC-death score categories. ABC-death score = age, biomarkers (N-terminal fragment B-type natriuretic peptide, high-sensitivity troponin, growth differentiation factor 15), and clinical history (heart failure).

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  Figure 2. Decision Curves Analysis for ABC-Death Score and CHA2DS2VASc Score This analysis shows the clinical usefulness of each score based on a continuum of potential thresholds (x-axis) for all-cause death (A) and cardiac death (B) and the net benefit of using the model to stratify patients at risk (y-axis) relative to assuming that no patient will suffer death risk. eGFR (CKD-EPI) = estimated glomerular filtration rate estimated using the Chronic Kidney Disease Epidemiology Collaboration Equation; other abbreviations as in Figure 1.

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  Figure 3. Calibration Curves for ABC-Death Score Calibration curves were plotted by comparison of the predicted event rate using the ABC-death score with the annualized observed all-cause (A) and cardiac mortality (B) event rate. ABC-death score overestimated event rate, especially for those with higher mortality risk. Abbreviations as in Figure 1.

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  Central Illustration. The ABC-Death Score Predicts Mortality After Atrial Fibrillation Ablations (A) The components of ABC-death score and the corresponding incidence rate of each risk group stratified using ABC-death score categories. (B) Association of preablation biomarkers (per 2-fold increase) with all-cause mortality and cardiac mortality. Black arrows mean increased mortality risk. (C) Discrimination of ABC-death score evaluated using C index and NRI. ABC-death score = age, biomarkers (N-terminal fragment B-type natriuretic peptide, high-sensitivity troponin, growth differentiation factor 15), and clinical history (heart failure); TnT-hs = high-sensitivity cardiac troponin T; GDF = growth differentiation factor; NRI = net reclassification index; NT-proBNP = N-terminal fragment B-type natriuretic peptide.