June 1, 1990Circulation Research

5-Hydroxytryptamine induces phospholipase C-mediated hydrolysis of phosphoinositides through 5-hydroxytryptamine-2 receptors in cultured fetal mouse ventricular myocytes.

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Population

Cultured fetal mouse ventricular myocytes labeled with [3H]inositol

Design

Preclinical

Authors

YHYasuo HamamoriNiigata University of Pharmacy and Medical and Life Sciences MYM YokoyamaCentre for Human Genetics MYMitsuhiko YamadaŌtani University

Discussion

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Implication

Hypothesis-generating for 5-HT2 signaling in ventricular myocytes; should not yet change clinical practice.

Structured PICO

Population

Cultured fetal mouse ventricular myocytes labeled with [3H]inositol

Intervention

5-Hydroxytryptamine (5-HT) stimulation

Outcome

Phospholipase C-mediated hydrolysis of phosphoinositides (accumulation of inositol monophosphate, inositol bisphosphate, and inositol trisphosphate)surrogate

5-HT directly stimulates phospholipase C-mediated hydrolysis of phosphoinositides via 5-HT2 receptors in ventricular myocytes, a pathway negatively regulated by protein kinase C.

Cite This Study

Hamamori et al. (1990) studied this question.

synapsesocial.com/papers/6a942903d3a1effb396d12ed https://doi.org/10.1161/01.res.66.6.1474

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5-Hydroxytryptamine induces phospholipase C-mediated hydrolysis of phosphoinositides through 5-hydroxytryptamine-2 receptors in cultured fetal mouse ventricular myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

5-Hydroxytryptamine induces phospholipase C-mediated hydrolysis of phosphoinositides through 5-hydroxytryptamine-2 receptors in cultured fetal mouse ventricular myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider