Key result
Global deletion of Timp4 in adult female mice resulted in higher ejection fraction to maintain stroke volume and was not detrimental to maternal heart function during first pregnancies and lactation.
Why the study?
Pregnancy and lactation increase volume load on the heart, where defects in cardiac remodeling can cause peripartum cardiomyopathy, and TIMPs participate in cardiac remodeling.
Does Timp4 deletion impact maternal cardiac function during pregnancy and lactation in mice?
Does Timp4 deletion impact maternal cardiac function during pregnancy and lactation in mice?
Global deletion of Timp4 in mice is not detrimental to maternal heart function during first pregnancies and lactation, but leads to a higher ejection fraction to maintain stroke volume.
Answers are grounded in this paper and cite their sources.
Timp4 deletion maintains murine maternal cardiac function in pregnancy; leaves open translational relevance to human peripartum remodeling.
Pregnancy and lactation increase volume load on the heart. Defects in cardiac remodeling during pregnancy and postpartum can result in peripartum cardiomyopathy. TIMPs participate in cardiac remodeling. The present study reports the cardiac function in Timp4 knockout adult female mice during pregnancy and lactation. Timp4 knockout females at many time points have higher ejection fraction to maintain stroke volume. Global deletion of Timp4 was not detrimental to maternal heart function during first pregnancies and lactation.
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Thurstin et al. (2022) studied Cardiac remodeling during pregnancy and lactation. Timp4 knockout was evaluated on Maternal heart function and ejection fraction. Global deletion of Timp4 in adult female mice resulted in higher ejection fraction to maintain stroke volume and was not detrimental to maternal heart function during first pregnancies and lactation.
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