The role of mitochondrial phosphoenolpyruvate carboxykinase in both hepatic and renal gluconeogenesis was studied in the chicken since this species reportedly lacks the cytosolic enzyme.Lactate is the major substrate used for glucose synthesis in isolated chicken hepatocytes but pyruvate, glycerol, and some amino acids, as well as lactate, are converted to glucose in isolated chicken kidney tubules.Renal gluconeogenesis and lactate production from pyruvate can be
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Watford et al. (1981) studied this question.
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