Enyne enyne oh! The first total synthesis of (+)-β-erythroidine, a non-aromatic Erythrina alkaloid, is demonstrated. The key steps involved are Lewis acid promoted cyclization of an epoxy–trichloroacetimidate intermediate and tandem ring-closing metathesis (RCM) of the dienyne (see scheme).
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Fukumoto et al. (2006) studied this question.
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