We have been investigating the synthesis and biological properties of 6-hydroxyethyl carbapenem com-pounds1 ~4) and demonstrated that meropenem (MEPM, la in Fig. 1) having a ljS-methyl group and the 5'dimethylammocarbonylpyrrolidin-3'-ylthio (DMAP)
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Sunagawa et al. (1997) studied this question.
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