Genetic screen uncovers transcriptional regulators driving stress resistance in Candida glabrata, highlighting pathways underlying antifungal and immune defense.
The mechanisms by which Candida glabrata resists host defense peptides and caspofungin are incompletely understood. To identify transcriptional regulators that enable C. glabrata to withstand these classes of stressors, a library of 215 C. glabrata transcriptional regulatory deletion mutants was screened for susceptibility to both protamine and caspofungin.
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Filler et al. (2020) studied this question.
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