Antibodies against glycosylated native MOG are elevated in patients with multiple sclerosis

Gaertner et al.1 recently reported an elevation of serum antibodies against a mammalian glycosylated myelin-oligodendrocyte-glycoprotein (MOG) in multiple sclerosis (MS). The results emphasize that anti-MOG autoimmunity may be important in monitoring MS. The authors also discuss that the “native” MOG conformation and glycosylation deserve further study and characterization.