Key result
Medical therapies such as anti-hypertensives, statins, and anti-platelet drugs are being investigated to slow abdominal aortic aneurysm growth, but definitive clinical evidence remains lacking.
Why the study?
The only established treatments for abdominal aortic aneurysms are open repair and endovascular repair, creating a need for less invasive medical treatments to slow growth or prevent rupture.
Do medical treatments slow aneurysm growth or prevent rupture in patients with abdominal aortic aneurysms?
Do medical treatments slow aneurysm growth or prevent rupture in patients with abdominal aortic aneurysms?
This review highlights the current lack of established medical therapies to prevent AAA growth and rupture, while suggesting potential future roles for anti-platelet agents like cilostazol that require further clinical investigation.
Abdominal aortic aneurysms (AAAs) usually expand asymptomatically until the occurrence of a life-threatening event such as aortic rupture, which is closely associated with high mortality. AAA and aortic dissection are ranked among the top 10 causes of death in Japan. The major risk factors for AAA are age over 65 years, male gender, family history, and smoking. Thus, for prevention, smoking cessation is the most important lifestyle-intervention. For treatment, since AAA generally affects elderly people, less invasive treatment is preferable. However, the only established treatment for AAA is open repair and endovascular repair. This review describes potential medical treatments to slow aneurysm growth or prevent AAA rupture.
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Umebayashi et al. (2019) conducted a review in Abdominal aortic aneurysms. Medical treatments (anti-hypertensives, statins, doxycycline, anti-platelet drugs) was evaluated. Medical therapies such as anti-hypertensives, statins, and anti-platelet drugs are being investigated to slow abdominal aortic aneurysm growth, but definitive clinical evidence remains lacking.
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