The hemoglobins of a child homozygous for the Lepore Boston gene have been analyzed. Only hemoglobin F and Lepore were observed. Hemoglobin Lepore was isolated and the peptide chains of this hemoglobin were separated. The amino acid composition of the Lepore chain and of the tryptic peptides obtained from this chain was determined. The peptides isolated accounted for the amino acid composition of the Lepore chain and indicated that this chain is 146 amino acid long. The switch region from the δ-like sequence of the Lepore chain to the β-like sequence has been localized between residue 87 and residue 116.
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Baglioni et al. (1968) studied this question.
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