Key result
Hypercholesterolemia was associated with significantly higher platelet superoxide anion production compared to healthy controls (p<0.001), which was reduced by 8-week atorvastatin treatment.
Why the study?
Does atorvastatin reduce platelet superoxide anion production in patients with hypercholesterolemia?
Observational (n=53)
Does atorvastatin reduce platelet superoxide anion production in patients with hypercholesterolemia?
p-value: p=<0.001
Atorvastatin reduces platelet superoxide anion production in hypercholesterolemic patients through mechanisms that are partially independent of its cholesterol-lowering effect.
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Supports statin pleiotropy on platelet oxidative stress; hypothesis-generating and should not yet change practice.
Sanguigni et al. (2002) conducted an observational in Hypercholesterolemia (n=53). Hypercholesterolemia vs. Healthy subjects was evaluated on Platelet superoxide anion (O2-) production (p=<0.001). Hypercholesterolemia was associated with significantly higher platelet superoxide anion production compared to healthy controls (p<0.001), which was reduced by 8-week atorvastatin treatment.
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