Key result
Vomiting, circulatory disturbance, enterovirus 71 infection, respiratory rhythm dysfunction, and high brain natriuretic peptide were independent risk factors for cardiopulmonary collapse in severe HFMD.
Case-Control (n=176)
Vomiting, circulatory disturbance, EV71 infection, respiratory rhythm dysfunction, and high BNP are independent risk factors for cardiopulmonary collapse in children with severe HFMD.
May aid early risk stratification in severe HFMD; hypothesis-generating and requires prospective validation before practice change.
BACKGROUND: The aim of this study was to investigate the risk factors for severe hand, foot and mouth disease (HFMD) complicated with cardiopulmonary collapse in children. METHODS: In total, 176 children aged 6-45 months with severe HFMD from March 2013 to May 2014 were enrolled in the study and divided into two groups, one with cardiopulmonary collapse and the other without. Univariate analysis and multiple logistic regression analysis were used to analyze the risk factors for severe HFMD complicated with cardiopulmonary collapse. RESULTS: The univariate analysis showed that there was no significant correlation between age, body temperature, consciousness disorders, blood glucose level and severe HFMD complicated with cardiopulmonary collapse. The multiple logistic regression analysis demonstrated that vomiting, circulatory disturbance, enterovirus 71 infection, dysfunction of respiratory rhythm and high level of brain natriuretic peptide were five independent risk factors for severe HFMD complicated with cardiopulmonary collapse. CONCLUSION: Children with HFMD and the above five risk factors may be at risk for cardiopulmonary collapse and poor prognosis.
No takes yet. Share an insight, caveat, or question.
Song et al. (2015) conducted a case-control in severe hand, foot and mouth disease (n=176). Risk factors including vomiting, circulatory disturbance, enterovirus 71 infection, respiratory rhythm dysfunction, and high BNP vs. Absence of risk factors was evaluated on Cardiopulmonary collapse. Vomiting, circulatory disturbance, enterovirus 71 infection, respiratory rhythm dysfunction, and high brain natriuretic peptide were independent risk factors for cardiopulmonary collapse in severe HFMD.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: