Key result
Improved renal extract preparation successfully reduces blood pressure in experimental hypertension.
Why the study?
The study and use of renal extracts to lower blood pressure in experimental hypertension has been hampered by small yield and difficulty concentrating activity.
Does an improved preparation procedure yield purified renal extracts suitable for isolating hypotensive principles in experimental hypertension?
Does an improved preparation procedure yield purified renal extracts suitable for isolating hypotensive principles in experimental hypertension?
Answers are grounded in this paper and cite their sources.
The study provides an improved methodology for the extraction and purification of hypotensive principles from renal tissue, facilitating further chemical study in experimental hypertension.
The capacity of certain renal extracts to lower the blood pressure in experimentally induced hypertension has been described (l), but the study and use of such extracts has been hampered by the small yield obtained from renal tissue and the difficulty of concentrating this activity. The present paper reports an improved procedure for preparing active extracts and the purification of these to a form suitable for chemical study and for attempts at isolation of the active hypotensive principle.
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Hamilton et al. (1958) studied Experimental hypertension. Preparation of renal extracts was evaluated. An improved procedure was developed for preparing and purifying active renal extracts capable of reducing blood pressure in experimental hypertension.
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