High-sensitivity proton detection enabled acquisition of well-resolved two-dimensional spectra in only 30 minutes for less than 5 mg of organic compounds at natural abundance. Besides faster resonance assignment, rapid analysis of crystal polymorphism, molecular dynamics, and H-bonding is possible. This method is applicable to both pure and dosage forms of solid pharmaceuticals, such as ibuprofen (see picture).
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Zhou et al. (2008) studied this question.
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