Key result
The rs1801020 variant in coagulation factor XII increased the risk of cardiovascular disease (HR 1.31), and multiple genetic variants showed significant gender-specific effects on cardiovascular risk.
Why the study?
Does genetic variation in 46 candidate genes confer gender-specific risk for coronary heart disease, ischemic stroke, and cardiovascular disease in Finnish population cohorts?
Population
14,140 individuals from two Finnish population cohorts. Case-cohort design including incident CHD cases…
Comparison
Common variation in 46 candidate genes vs Different genders and non-carriers
Design
Cohort
Follow-up
10 years (FINRISK-92) and 7 years (FINRISK-97)
Authors
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rs1801020 variant was associated with CVD risk; leaves open gender-specific effects for risk stratification pending replication.
Cohort (n=2,200)
Does genetic variation in 46 candidate genes confer gender-specific risk for coronary heart disease, ischemic stroke, and cardiovascular disease in Finnish population cohorts?
Hazard Ratio: 1.31 (95% CI 1.08–1.6)
p-value: p=0.006
Genetic risk loci for cardiovascular disease may be more readily detectable and have stronger gender-specific effects in women compared to men.
Silander et al. (2008) conducted a cohort in Cardiovascular disease (n=2,200). Common variation in 46 candidate genes vs. Reference genotypes was evaluated on Cardiovascular disease (CVD) (HR 1.31, 95% CI 1.08-1.60, p=0.006). The rs1801020 variant in coagulation factor XII increased the risk of cardiovascular disease (HR 1.31), and multiple genetic variants showed significant gender-specific effects on cardiovascular risk.
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