Key result
The presence of P pulmonale on electrocardiogram significantly predicted in-hospital mortality among male patients with acute exacerbation of COPD (OR 2.135).
Why the study?
Spirometry is costly, requires conscious effort, and is not readily available in rural settings, whereas ECG is accessible and affordable, leading investigators to evaluate ECG findings for predicting mortality in acute exacerbation of COPD.
Do electrocardiographic findings of p pulmonale and right ventricular hypertrophy predict mortality in male patients with acute exacerbation of COPD?
Observational (n=101)
No
Do electrocardiographic findings of p pulmonale and right ventricular hypertrophy predict mortality in male patients with acute exacerbation of COPD?
The presence of p pulmonale and right ventricular hypertrophy on a standard 12-lead ECG are significant independent predictors of mortality in patients admitted with acute exacerbations of COPD.
An exacerbation of COPD is defined as an acute worsening of respiratory symptoms that result in additional therapy. COPD is currently the fourth leading cause of death in the world. There is a need for prospective trials in COPD based on hard clinical outcomes such as death to bring improvements in clinical managements. Chronic obstructive pulmonary disease (COPD) ranks fourth as a cause of death in the United States, behind heart disease, cancer, and stroke. COPD is a costly disease with both direct costs (value of health care resource devoted to diagnosis and management) and indirect costs (monetary consequences of disability, missed work, premature mortality and caregiver or family costs resulting from the illness 1) . Diagnostics test for COPD is spirometry FEV1/FVC. Spirometry is costly and is not readily available in rural settings and the technique to perform spirometry involves a lot of patient's conscious effort. Whereas ECG is easily available, affordable, does not require patient's conscious effort. We wanted to predict the electrocardiographic findings predicting mortality in acute exacerbation of COPD.
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Balagopalan et al. (2019) conducted an observational in Acute exacerbation of COPD (n=101). Electrocardiographic findings of P pulmonale vs. Absence of P pulmonale was evaluated on Mortality (OR 2.135, 95% CI 1.473-3.093, p=0.004692). The presence of P pulmonale on electrocardiogram significantly predicted in-hospital mortality among male patients with acute exacerbation of COPD (OR 2.135).
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