Key result
Acetylcholinesterase inhibitor therapy in elderly Alzheimer's patients did not significantly alter balance, gait, or orthostatic hypotension prevalence at 6 months compared to baseline (P > .05).
Why the study?
Does acetylcholinesterase inhibitor therapy affect balance, gait, and orthostatic hypotension in elderly patients with Alzheimer's disease?
Observational (n=102)
Does acetylcholinesterase inhibitor therapy affect balance, gait, and orthostatic hypotension in elderly patients with Alzheimer's disease?
p-value: p=> .05
Acetylcholinesterase inhibitors do not worsen orthostatic hypotension and may improve balance in Alzheimer's patients who experience cognitive benefits.
Reassures on balance and orthostatic stability in cohort data; leaves open definitive safety assessment in randomized studies.
OBJECTIVE: The present study was designed to evaluate the effect of acetylcholinesterase inhibitor (AchEI) therapy on balance, gait, and orthostatic hypotension (OH) in elderly patients with Alzheimer's disease (AD). METHODS: A total of 102 elderly patients with AD have been recently diagnosed and were treated with AchEI and underwent comprehensive geriatric assessment at baseline and at the end of the sixth month. RESULTS: Timed Up and Go test and Tinetti Performance-Oriented Mobility Assessment values and the prevalence of OH were not different at the end of the sixth month versus baseline (P > .05). However, it was determined that changes in balance were better in the patients who showed cognitive improvement at the end of the sixth month (P < .05). CONCLUSION: Curative effects of AchEIs, which are used in the treatment of AD, on cognitive performance are reflected also in balance functions. Moreover, it was observed that these drugs do not increase the prevalence of OH.
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Işık et al. (2016) conducted an observational in Alzheimer's disease (n=102). Acetylcholinesterase inhibitor (AchEI) vs. Baseline was evaluated on Timed Up and Go test, Tinetti Performance-Oriented Mobility Assessment values, and prevalence of orthostatic hypotension (p=> .05). Acetylcholinesterase inhibitor therapy in elderly Alzheimer's patients did not significantly alter balance, gait, or orthostatic hypotension prevalence at 6 months compared to baseline (P > .05).
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